PHVSNasdaqPharmaceutical PreparationsUS GAAP · USD

Pharvaris N.V.

Pharvaris N.V. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies for rare diseases, with initial emphasis on angioedema and other bradykinin-mediated conditions. The group is organized through subsidiaries in the Netherlands, the United States, and Switzerland, with its corporate base in Leiden, the Netherlands.

Operating profit (EBIT)-170m USD
−16.6 %y/y
Net income-176m USD
−30.9 %y/y
Free cash flow-137m USD
−13.7 %y/y

Fiscal year 2025 · change from previous year

Development 2022–2025

-200-150-100-500m USD2022: 0.00 m USD2022: EBIT -87 m USD20222023: 0.00 m USD2023: EBIT -97 m USD20232024: 0.00 m USD2024: EBIT -146 m USD20242025: EBIT -170 m USD2025-170
RevenueOperating profit (EBIT)

Business

Share of revenue
Rare disease therapeutics100 %

Drug candidates and planned medicines for rare bradykinin-mediated disorders such as angioedema.

Customers

Pharvaris does not sell broad consumer products; its end users are patients with rare bradykinin-mediated diseases, while its immediate commercial counterparts are physicians, specialty distributors, and healthcare systems that would prescribe, stock, and administer approved therapies. In the development stage, the company’s economic relationship is primarily with regulators, investigators, clinical sites, and future payers that determine access and reimbursement. Rare-disease treatments are typically bought because they address serious unmet medical need and can offer differentiated convenience or efficacy.

Patients with rare bradykinin-mediated diseases

Potential end users of the company's therapies, seeking prevention or treatment of angioedema attacks.

Specialist physicians

Allergists, immunologists, and other specialists who diagnose and prescribe therapies.

Payers and reimbursement authorities

They determine formulary access, coverage, and patient affordability after approval.

Clinical trial sites

Hospitals and research centers that enroll patients and generate development data.

Strategy

The company’s strategy is to advance its rare-disease pipeline through clinical development and regulatory review, then position candidate therapies for commercialization if approved. It is also building the operational and corporate structure needed to support global development and future launch in target markets where hereditary angioedema is treated. Protecting intellectual property and maintaining access to funding are central because the model depends on completing long development cycles before meaningful product revenue.

Late-stage clinical developmentShort term

Progressing candidates through trials is the main value driver before any product revenue exists.

Regulatory pathway executionMedium term

Approval is required before the company can monetize its pipeline.

Commercial readinessMedium term

Rare-disease launches require medical affairs, market access, and distribution capabilities.

Geography

Pharvaris is headquartered in Leiden, the Netherlands, and operates through entities in the Netherlands, the United States, and Switzerland. The available reports do not disclose revenue by geography, which is consistent with a development-stage company that has not yet established broad commercial sales. Its geographic footprint matters mainly for clinical operations, regulatory submissions, intellectual property, and future market launch planning across the U.S. and Europe.

Risks

Pharvaris faces the typical biotechnology risks of clinical failure, regulatory delay, and difficulty raising capital before product revenue is established. The company also depends on intellectual property protection, manufacturing readiness, and eventual market acceptance in a rare-disease market where reimbursement and launch execution are critical. Because its business is still development-focused, any setback in trials or approvals could materially affect valuation and future financing needs.

Sorted by severity
LowMediumHighLowMediumHighImpact →Likelihood →Clinical development failure1Regulatory approval risk2Financing risk3Intellectual property risk4
Impact is the risk’s severity and likelihood how probable it is over the next few years, both assessed from the company’s reports. Numbers match the list.
  1. Clinical development failureImpact: CriticalLikelihood: Medium

    The business depends on proving that its product candidates are safe and effective in rare diseases.

    Exposure: Pipeline programs for angioedema and related conditions

  2. Regulatory approval riskImpact: CriticalLikelihood: Medium

    Commercialization requires approval from the FDA and other agencies, which may impose delays or restrictions.

    ExposureU.SEUOther jurisdictions
  3. Financing riskImpact: HighLikelihood: Medium

    Development-stage biotech typically consumes cash before generating product sales and may need new capital.

    Exposure: Operating funding and future launches

  4. Intellectual property riskImpact: HighLikelihood: Medium

    Loss of patent or know-how protection could reduce the value of the pipeline and future exclusivity.

    Exposure: Product candidates and commercialization rights

Accounting

Judgemental items
Development-stage expense recognition

Clinical and regulatory spending is expensed as incurred, shaping reported losses before commercialization.

Impact: Materially affects operating loss and cash burn

Share issuance accounting

Equity financing changes cash, share capital, and transaction costs in financing activities.

Impact: Affects liquidity and dilution

Lease accounting

Lease principal repayments and liabilities are recognized separately under IFRS 16.

Impact: Affects cash flow classification and balance sheet obligations

Going concern assessment

Management must assess whether existing funding supports operations for at least 12 months.

Impact: Important for liquidity disclosure and investor confidence

Foreign currency translation

The group reports in euros while operating entities may incur balances in other currencies.

Impact: Can create exchange-rate gains or losses in cash and equity

Publicly listed companies with a comparable business focus.

Last updated: 28/09/2026