CRLNYSEServices-Commercial Physical & Biological ResearchUS GAAP · USD

Charles River Laboratories International, Inc

Charles River Laboratories International, Inc. is a contract research, development, and manufacturing services company that supports drug discovery and non-clinical development for biopharmaceutical and other life science customers. Founded in 1947 and headquartered in Wilmington, Massachusetts, it operates across early-stage research, safety assessment, and manufacturing support. The company’s model is built around outsourcing scientific work that customers do not want to perform fully in-house, especially in the preclinical phase of drug development. Its portfolio spans discovery services, laboratory models and research support, non-clinical safety testing, and selected manufacturing-related services. Charles River competes on scientific expertise, regulatory quality, responsiveness, and global delivery capabilities. It serves a broad customer base that includes large pharma, biotech, academic institutions, government agencies, and other commercial life science organizations.

Revenue4,015m USD
−0.9 %y/y
Operating profit (EBIT)25.2m USD
−88.9 %y/y
EBIT margin0.6%
−5.0 ppy/y
Net income-144m USD
−750.1 %y/y
Free cash flow738m USD
+0.4 %y/y

Fiscal year 2025 · change from previous year

Development 2020–2025

01,0002,0003,0004,0005,000m USD2020: 2,924 m USD2020: EBIT 433 m USD20202021: 3,540 m USD2021: EBIT 590 m USD20212022: 3,976 m USD2022: EBIT 651 m USD20222023: 4,129 m USD2023: EBIT 617 m USD20232024: 4,050 m USD2024: EBIT 227 m USD20242025: 4,015 m USD2025: EBIT 25 m USD20254,01525
RevenueOperating profit (EBIT)

Business

Share of revenue
Research Models and Services (RMS)28 %

Laboratory animal models, related research support, and services used in preclinical research workflows.

Discovery and Safety Assessment (DSA)47 %

Discovery services and non-clinical safety testing that help customers advance drug candidates toward development.

Manufacturing Support25 %

Microbial Solutions and biologics-related services that support quality control and biologics production workflows.

Products

Reported · share of revenue
80.9%19.1%FY2025100 %
  • Services80.9 %
  • Products19.1 %

Source: 10-K FY2025, revenue the company reports per product line (SEC XBRL). Shares are of the lines shown and add up to 100 %.

Customers

Charles River sells primarily to biopharmaceutical companies that outsource early-stage research, safety testing, and selected manufacturing support rather than building all capabilities internally. It also serves biotechnology companies, including emerging and mid-sized firms that need flexible access to specialized scientific infrastructure. Additional customers include agricultural and industrial chemical companies, life science and veterinary medicine companies, medical device and diagnostic firms, consumer product companies, contract research organizations, and contract manufacturing organizations. Universities, teaching hospitals, government agencies, and non-governmental organizations also buy from the company, especially for research and testing services. Demand is tied to customers’ R&D budgets and development pipelines, so spending patterns in pharma and biotech directly affect Charles River’s volumes.

Major biopharmaceutical companies

Buy discovery, safety assessment, and manufacturing support to accelerate pipelines and reduce internal fixed costs.

Biotechnology companies

Use outsourced scientific capacity for early-stage research and non-clinical development, especially when internal infrastructure is limited.

Contract research and manufacturing organizations

Purchase specialized services and support capabilities to complement their own outsourced development and production offerings.

Academic, government, and non-profit research organizations

Buy research models, testing, and scientific services for research programs and regulated studies.

Other life science and regulated product companies

Includes medical device, diagnostic, veterinary, agricultural, and consumer product customers that need testing and compliance-oriented support.

Strategy

Charles River’s strategy is centered on being a preferred outsourced partner across the early drug discovery and non-clinical development chain. The company emphasizes scientific expertise, regulatory compliance, quality, responsiveness, and flexible solutions that can be scaled across client programs. It also seeks to deepen relationships with large biopharmaceutical customers through preferred provider arrangements and strategic partnerships that encourage cross-selling across the non-clinical portfolio. Management is also focused on disciplined capital allocation, including infrastructure investment, selective acquisitions and divestitures, and share repurchases. In the near term, the company is managing through cautious client spending and a softer demand environment in parts of DSA while supporting growth in RMS and Manufacturing.

Grow preferred-provider relationships with large biopharma clientsMedium term

These relationships improve visibility, increase wallet share, and support recurring multi-service demand.

Cross-sell across the non-clinical portfolioShort term

Bundling discovery, safety, and manufacturing support increases customer stickiness and broadens revenue per client.

Maintain disciplined capacity and capital spendingShort term

The business is capital intensive and must align infrastructure with demand to protect returns.

Optimize portfolio through acquisitions and divestituresMedium term

Portfolio actions can improve strategic focus and redeploy capital toward higher-value capabilities.

Geography

Q1/2026

Charles River describes itself as having broad geographic availability with consistent quality, which matters because customers often want the same standards across multiple study locations. The company is headquartered in the United States, but it operates globally and explicitly references revenue and long-lived assets across the United States, Europe, Canada, Asia Pacific, and other countries. Its competitive set also spans the U.S., Europe, China, Canada, and Japan, showing that the business is embedded in a global outsourced R&D market. The company holds most of its cash outside the U.S., indicating meaningful non-U.S. operating exposure. Geography matters operationally because regulatory standards, customer proximity, and currency movements can affect utilization, pricing, and margins.

United States55 %
Europe28 %
Canada11 %
Asia Pacific5.6 %

Share of the revenue the company reports by geography.

Risks

Charles River is exposed to demand swings in pharmaceutical and biotechnology R&D, because its services are discretionary inputs to customers’ development budgets. The company also bears contract execution risk, including termination, scope reduction, underpricing, cost overruns, and delays, which can pressure margins in project-based work. Cybersecurity and confidentiality are important risks because the company handles sensitive study data and relies on third-party software and cloud infrastructure; a breach could damage customer trust and trigger legal or regulatory consequences. Competitive pressure is intense across all three segments, including in-house client capabilities and numerous global competitors in China, Europe, Canada, Japan, and the U.S. In addition, venture capital and strategic equity investments add earnings volatility through gains, losses, and impairments that are not tied to core operating performance.

Sorted by severity
LowMediumHighLowMediumHighImpact →Likelihood →Cyclicality in pharma and biotech R&D spending1Contract scope reduction, termination, and pricing pressure2Cybersecurity and confidentiality breaches3
Impact is the risk’s severity and likelihood how probable it is over the next few years, both assessed from the company’s reports. Numbers match the list.
  1. Cyclicality in pharma and biotech R&D spendingImpact: HighLikelihood: Medium

    The company depends on customer budgets for outsourced discovery, testing, and manufacturing support, so lower R&D spending reduces volumes.

    Exposure: DSA and RMS demand

  2. Contract scope reduction, termination, and pricing pressureImpact: HighLikelihood: Medium

    Project-based contracts can be reduced or repriced, creating revenue and margin risk if utilization falls or costs are fixed.

    Exposure: All segments

  3. Cybersecurity and confidentiality breachesImpact: HighLikelihood: Medium

    The company stores sensitive client study data and relies on third-party IT infrastructure, so a breach could cause legal, reputational, and commercial harm.

    Exposure: Client data and study records

  4. Competitive intensity from global CROs and in-house capabilitiesImpact: Medium

    Customers can shift work to internal labs or alternative providers, pressuring pricing and utilization.

    ExposureDiscoverySafety assessmentManufacturing support
  5. Investment losses and impairments from venture capital portfolioImpact: Medium

    Non-operating investment marks can materially affect net income even when core operations are stable.

    Exposure: Other expense / non-operating income

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Accounting

Judgemental items
Revenue recognition for services and manufacturing support

The company must determine when performance obligations are satisfied, which affects timing of revenue and margin recognition.

Impact: Can shift revenue between quarters and affect reported growth

Goodwill and intangible asset amortization/impairment

Acquisitions create significant intangible balances that require ongoing amortization and impairment testing.

Impact: Can materially affect operating income and equity

Contingent consideration

Acquisition earn-outs and similar obligations depend on future performance and require remeasurement.

Impact: Can create earnings volatility and cash outflows

Venture capital and strategic equity investments

These holdings are marked or impaired based on fair value and performance, not core operations.

Impact: Can materially affect other income/expense and net income

Allowance for credit losses

Customer payment risk can rise when demand softens, requiring updated reserve estimates.

Impact: Affects operating expenses and receivables valuation

Publicly listed companies with a comparable business focus.

Last updated: 24/09/2026

Charles River Laboratories International, Inc (CRL) Revenue, Earnings & Financials 2025 – Clarifo